What is the clinical features of CLL?
Enlarged, but painless, lymph nodes. Fatigue. Fever. Pain in the upper left portion of the abdomen, which may be caused by an enlarged spleen.
What is the most common presenting symptom in patients with CLL?
Enlarged lymph nodes are the most common presenting symptom, seen in 87% of patients symptomatic at time of diagnosis. A predisposition to repeated infections such as pneumonia, herpes simplex labialis, and herpes zoster may be noted. Early satiety and/or abdominal discomfort may be related to an enlarged spleen.
How is CLL SLL diagnosed?
CLL can be diagnosed on a blood test. SLL is usually diagnosed by taking a sample of cells from a swollen lymph node to look at under a microscope. This is called a lymph node biopsy. A doctor either uses a hollow needle to remove a ‘core’ of tissue from a lymph node (a ‘needle core biopsy’), or removes the whole node.
What are the laboratory findings in patient with chronic lymphocytic leukemia?
Having more than 10,000 lymphocytes/mm³ (per cubic millimeter) of blood strongly suggests CLL, but other tests are needed to know for sure. You might also have low levels of red blood cells and platelets. A sample of blood is looked at under the microscope (called a peripheral blood smear).
How does SLL differ from CLL?
CLL (chronic lymphocytic leukemia) and SLL (small lymphocytic lymphoma) are the same disease, but in CLL cancer cells are found mostly in the blood and bone marrow. In SLL cancer cells are found mostly in the lymph nodes.
What is the difference between CLL and SLL?
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are cancers that affect lymphocytes. CLL and SLL are essentially the same diseases, with the only difference being the location where the cancer primarily occurs.
What is worse CLL or SLL?
Lymphocytes are a type of white blood cell. Both cancers are so similar that healthcare professionals often group them as CLL/SLL. Due to the similarity between the two conditions, there is no difference in how doctors approach their treatment.
What is the most important lab finding with chronic lymphocytic leukemia?
Flow cytometry, also called immunophenotyping, is the most important test to confirm a diagnosis of CLL.
What labs are abnormal with leukemia?
Your doctor will conduct a complete blood count (CBC) to determine if you have leukemia. This test may reveal if you have leukemic cells. Abnormal levels of white blood cells and abnormally low red blood cell or platelet counts can also indicate leukemia.
What happens with SLL?
SLL/CLL can inhibit the immune system and make fighting infections more difficult. It can also cause the immune system to attack itself which is known as autoimmunity. When this occurs, two life-threatening conditions may develop.
Which is worse SLL or CLL?
In fact, CLL and SLL are really the same disease. Sometimes patients with SLL can develop a rising white blood cell count in the blood (or leukemia), and patients with CLL invariably have CLL cells also in the lymph nodes. In addition, most cases of SLL become CLL over time.
What does CBC look like in leukemia?
Complete blood count (CBC): This blood test lets your healthcare provider know if you have abnormal levels of red blood cells, white blood cells and platelets. If you have leukemia, you’ll likely have higher than normal counts of white blood cells.
What labs are abnormal with lymphoma?
Complete blood count (CBC). This test measures the number of blood cells in a sample, including red blood cells, white blood cells, and platelets. A low level of red blood cells, white blood cells or platelets may indicate that the lymphoma is present in the bone marrow and/or blood.
What is the prognosis for SLL?
Small Lymphocytic Lymphoma Survival Rates The five-year survival rate for SLL in the United States is 86.9 percent. This means that, for every 100 people diagnosed with SLL now, about 87 people are expected to be alive in five years. This survival rate also applies to people with CLL.
What are the symptoms of small cell lymphoma?
The symptoms of CLL/SLL include a tender, swollen abdomen and feeling full even after eating only a small amount. Other symptoms can include fatigue, shortness of breath, anemia, bruising easily, night sweats, weight loss, and frequent infections.
Can SLL turn into CLL?
Sometimes patients with SLL can develop a rising white blood cell count in the blood (or leukemia), and patients with CLL invariably have CLL cells also in the lymph nodes. In addition, most cases of SLL become CLL over time.