What is AS04 adjuvant?

Adjuvant System 04 or AS04 is a trade name for combination of adjuvants used in various vaccine products by GlaxoSmithKline, in particular the Fendrix hepatitis B vaccine. It is also one of the ingredients of the human papillomavirus vaccine (HPV).

What is amorphous aluminum hydroxyphosphate sulfate?

Amorphous Aluminum Hydroxyphosphate Sulfate (AAHS) is an additive in Gardasil meant to produce a stronger and longer immune response. Aluminum, however, is known to be neurotoxic if it accumulates in the brain.

What is Monophosphoryl lipid A?

A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TL= R4) agonist, with potential immunostimulatory activity.

Which vaccines contain MF59?

The MF59-adjuavanted inactive trivalent influenza vaccine (TIV) [Fluad®, MF59-adjuvanted trivalent influenza vaccine (ATIV), Novartis Vaccines] contains 15 μg of each influenza strain surface antigen and the MF59 adjuvant and is administered as a 0.5 ml dose.

What vaccines use MF59?

The newly approved vaccine, Fluad Quadrivalent, uses the same MF59 adjuvant as the Fluad vaccine, but with an additional strain included. A study in Clinical Infectious Diseases published in December 2019, demonstrated that enhanced flu vaccines can provide better protection for older adults.

How long does the Shingrix vaccine last?

With Shingrix, you get two shots between 2 and 6 months apart and protection lasts an estimated 4-5 years. Doctors recommend it for healthy people over 50 as well as those 19 years of age and older who are or will be immunodeficient or immunosuppressed due to disease or therapy..

Is it OK to get Shingrix and flu shot together?

Coadministration of Shingrix with adjuvanted influenza vaccine (Fluad) and COVID-19 vaccines is being studied. Shingrix and pneumococcal vaccine can be administered at the same visit if the person is eligible for both.

Who manufactures HPV vaccine?

Currently, only two manufacturers, MSD and GSK, produce WHO-prequalified HPV vaccines. Several others are developing HPV vaccines – including Innovax (whose vaccine is currently under review for WHO prequalification), as well as Serum Institute of India and Walvax.

What metals are in HPV vaccine?

The ingredients are proteins of HPV Types 6, 11, 16, and 18, amorphous aluminum hydroxyphosphate sulfate, yeast protein, sodium chloride, L-histidine, polysorbate 80, sodium borate, and water for injection.

What CpG 1018?

CpG 1018 is the adjuvant contained in HEPLISAV-B®, the Company’s U.S. FDA-approved hepatitis B vaccine.

What does lipid A do?

Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane.

Who makes MF59 adjuvant?

Seqirus has combined two technologies—MF59® adjuvant and cell-based antigen manufacturing—to create this first-of-its-kind pandemic influenza vaccine.

AS04 (Aka. “Adjuvant System 04”) is a trade name for combination of adjuvants used in various vaccine product by GlaxoSmithKline (GSK), in particular the Fendrix Hepatitis B vaccine. It consists of aluminum hydroxide and monophosphoryl lipid A (MPL).

What is the composition of the adjuvant AS03?

It consists of aluminum hydroxide and monophosphoryl lipid A (MPL). Furthermore, it is the successor of AS03 which is a squalene based adjuvant approved for pandemic vaccine by the EMA.

What do we know about the mechanism of action of adjuvants?

Adjuvants currently in widespread use, either in man or in animals, have for the most part been developed empirically, without a clear understanding of their cellular and molecular mechanisms of action.

What is the history of adjuvants?

The concept of adjuvants was first focused by Ramon, 1925, Ramon, 1926 emerged from observations that an abscess at the inoculation site produced higher specific antibody titers. Generally, adjuvants can be used for various purposes ( Aguilar and Rodriguez, 2007 ):