Does overexpression of Myc cause cancer?
MYC is documented to be involved broadly in many cancers, in which its expression is estimated to be elevated or deregulated in up to 70% of human cancers. High levels of MYC expression have been linked to aggressive human prostate cancer and triple negative breast cancer (Gurel et al., 2008; Palaskas et al., 2011).
Does c-Myc cause cancer?
The c-Myc oncogene is overexpressed in the majority of human cancers and contributes to the cause of at least 40% of tumors37.
What is c-Myc in cancer?
c-Myc is a transcription factor that belongs to the basic-helix-loop-helix-leucine zipper (bHLHZip – Fig. 1a) family present in the cell nucleus, where it acts to regulate cell growth, differentiation, metabolism and death, and is frequently dysregulated in many human cancers [1].
What does overexpression of Myc do?
MYC overexpression in the embryonic liver induces cellular proliferation, whereas in adult liver it promotes cellular growth without mitotic division that is associated with polyploidy (Beer et al. 2004).
What is the difference between c-Myc and Myc?
Myc and c-myc are the same thing, the normal cellular (hence the c) version of this protein, which can be oncogenic when mutated. The myc tag is a 10-residue sequence derived from c-myc, which is a much larger protein.
Is c-Myc a tumor suppressor gene?
The tumor suppressor p53 is a master gene regulator controlling diverse cellular pathways, by either activating or repressing downstream genes. Among such genes is the proto-oncogene c-Myc, which is negatively regulated by p53 (1).
What is the difference between c-Myc and MYC?
What does c-Myc regulate?
C-Myc. C-Myc protein is a member of a family of proteins that regulate cell proliferation and apoptosis. The ability of c-myc to regulate apoptotic cell death results from the coordinated activation of c-Myc and several protein partners (such as Max) that facilitate DNA binding and activate transcription.
Is c-myc the same as Myc?
What does c-myc regulate?
Where is c-Myc expressed?
chromosome 8
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).
What is the difference between c-myc and MYC?
What does C-MYC regulate?
Where is C-MYC expressed?
What is the difference between C-MYC and MYC?