Which has less side effects dutasteride or finasteride?

San Francisco-Although similarly effective for the relief of lower urinary tract symptoms, fewer sexual side effects were observed with finasteride (Proscar) compared to dutasteride (Avodart) in a retrospective study of men with BPH, Steven A. Kaplan, MD, reported at the AUA annual meeting.

Is dutasteride better than finasteride for BPH?

One hundred and twenty men with symptomatic BPH were treated with dutasteride followed by an additional 120 men treated consecutively with finasteride for 3 months. Among patients who received dutasteride, there were significantly greater reductions in AUA symptom scores compared with those treated with finasteride.

Why dutasteride is not FDA approved?

The GlaxoSmithKline (GSK) drug Avodart (dutasteride), already approved for treatment in men with enlarged prostate glands, has been rejected by the FDA for the additional indication of reducing the risk of prostate cancer. An FDA advisory panel voted 14-2 on Dec. 1 to recommend against the expanded use of the drug.

Is dutasteride more effective than finasteride?

One study discovered that dutasteride was approximately three times more potent than finasteride in inhibiting type 2 5AR and 100 times more potent in inhibiting type 1 5AR. After studying the mechanism of action of two drugs, dutasteride was found to be theoretically more effective than finasteride in treating AGA.

Is dutasteride carcinogenic?

WASHINGTON — The FDA has issued a warning of an increased risk of high-grade prostate cancer with the 5-alpha reductase inhibitors finasteride (Proscar) and dutasteride (Avodart), currently approved to treat benign prostatic hypertrophy.

Will dutasteride regrow hair?

Dutasteride is mainly used to fight hair fall, however it can also be used to regrow hair as well. Men suffering from male pattern baldness have high levels of dihydrotestosterone or simply, DHT.

Is dutasteride 0.5 mg safe?

In the 4-year, phase III trial in benign prostate hyperplasia, 0.5 mg of dutasteride was well tolerated in long-term use. 11, 12 These reports including our data suggest that 0.5 mg of dutasteride treatment is effective and well tolerated in male patients with MPHL.

How long does it take for DHT to return to normal after dutasteride?

Dutasteride does not bind to the human androgen receptor. Effect on 5α-Dihydrotestosterone and Testosterone: The maximum effect of daily doses of dutasteride on the reduction of DHT is dose dependent and is observed within 1 to 2 weeks.

What are the long-term side effects of dutasteride?

Long-term dutasteride therapy, however, resulted in increased blood glucose, HbA1c, TC and LDL levels, ALT and AST activities, AMS Score and reduced T levels and worsened ED as assessed by the IIEF-EF scores. No worsening of ED, glucose, HbA1c, ALT, AST, AMS were observed in men treated with tamsulosin.

How fast does dutasteride lower DHT?

Dutasteride reduced the serum DHT levels from baseline by 84% at 2 weeks and by approximately 90% at 1, 2, 3, and 4 months compared with a 5.2% increase in the control group. The decrease in DHT levels with dutasteride was accompanied by a reciprocal increase in the serum and intraprostatic testosterone levels.

How long dutasteride can be taken?

Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the capsules whole; do not open chew, or crush them. Your symptoms may improve after you have taken dutasteride for 3 months, but it may take 6 months or longer for you to see the full benefit of dutasteride.

What is the difference between dutasteride and finasteride?

Dutasteride and finasteride are drugs typically used to treat symptoms of BPH or an enlarged prostate. Dutasteride is generic for Avodart, and finasteride is generic for Proscar and Propecia. These medications are also used to treat other conditions.

Who should avoid taking dutasteride and finasteride?

Women who are pregnant should avoid these drugs. These drugs can absorb through your skin when you handle them. Women who are pregnant should not handle them. Women who do touch a dutasteride capsule or a finasteride tablet should wash their hands immediately with soap and water. Men who take this drug should take precautions not to transfer it.

How does finasteride interact with other medications?

An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. Finasteride does not have any known drug interactions. Dutasteride can interact with the following drugs: Taking any of these drugs with dutasteride may slow how your liver breaks down dutasteride.

How soon can I donate blood after taking dutasteride and finasteride?

Men who take dutasteride should wait 6 months after their last dose to donate blood. Finasteride leaves your body a lot more quickly, so men who take finasteride should wait 72 hours after their last dose to donate blood. Waiting these periods can help you avoid exposing pregnant women to either drug if they receive your blood.